Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses

ER Job; B Bottazzi; B Gilbertson; KM Edenborough; LE Brown; A Mantovani; AG Brooks; PC Reading

Journal article

Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses

ER Job, B Bottazzi, B Gilbertson, KM Edenborough, LE Brown, A Mantovani, AG Brooks, PC Reading

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013

DOI: 10.1371/journal.pone.0059623

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Abstract

Members of the pentraxin family, including PTX3 and serum amyloid P component (SAP), have been reported to play a role in innate host defence against a range of microbial pathogens, yet little is known regarding their antiviral activities. In this study, we demonstrate that human SAP binds to human influenza A virus (IAV) strains and mediates a range of antiviral activities, including inhibition of IAV-induced hemagglutination (HA), neutralization of virus infectivity and inhibition of the enzymatic activity of the viral neuraminidase (NA). Characterization of the anti-IAV activity of SAP after periodate or bacterial sialidase treatment demonstrated that α(2,6)-linked sialic acid residues on..

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University of Melbourne Researchers

Brad Gilbertson Author

Lorena Brown Author

Andrew Brooks Author

Patrick Reading Author

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Natural inhibitors of influenza infection

This study will characterize the ability of soluble proteins in airway secretions to recognize and destroy influenza viruses. As many of our..

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Awarded by European Commission

Funding Acknowledgements

This work was supported by Project Grant #1032079 from the National Health and Medical Research Council (NHMRC) of Australia. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. The financial support of the European Research Council (ERC project HIIS) and of the European Commission (FP7-HEALTH-2011-ADITEC-280873) is gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.